Safety disclaimer
PGxAI Clinical Engine v2 is an educational clinical decision-support prototype, not medical advice. It does not diagnose, prescribe, guarantee response, or replace clinician judgment. Outputs describe relative PGx compatibility in this prototype and require professional interpretation before any clinical action.
Simple mode
Enter genotype, derive metabolizer phenotype
Simple Search starts from CYP2D6, CYP2C19, and optional CYP2B6 star-allele diplotypes. Missing clinical context lowers confidence rather than creating certainty.
Example meaning: normal function / normal function
Example meaning: normal function / normal function
Example meaning: optional input omitted
*1/*1
CYP2D6 *1/*1 maps to normal metabolizer in the prototype resolver.
Activity score: 2
Panel genotyping selected; phenotype confidence depends on allele coverage.
- *1: normal function
- *1: normal function
*1/*1
CYP2C19 *1/*1 maps to normal metabolizer in the prototype resolver.
Panel genotyping selected; phenotype confidence depends on allele coverage.
- *1: normal function
- *1: normal function
unknown
CYP2B6 could not be resolved confidently; the engine lowers confidence instead of assuming a phenotype.
Panel genotyping selected; phenotype confidence depends on allele coverage.
No-call or missing diplotype.
This prototype maps common star-allele diplotypes to metabolizer phenotypes locally. Functional phenotypes may differ from genetic phenotypes after phenoconversion modeling from current medications.
Run an evaluation to generate ranked antidepressants, score breakdowns, activated rules, missing-data warnings, phenoconversion assessment, and exportable report data.