Safety disclaimer
PGxAI Clinical Engine v2 is an educational clinical decision-support prototype, not medical advice. It does not diagnose, prescribe, guarantee response, or replace clinician judgment. Outputs describe relative PGx compatibility in this prototype and require professional interpretation before any clinical action.
Detailed mode
PGx genotype section
Enter CYP2D6, CYP2C19, and optional CYP2B6 star-allele diplotypes. The engine separates genetic phenotype from functional phenotype after phenoconversion.
Example meaning: normal function / normal function
Example meaning: normal function / normal function
Example meaning: optional input omitted
*1/*1
CYP2D6 *1/*1 maps to normal metabolizer in the prototype resolver.
Activity score: 2
Panel genotyping selected; phenotype confidence depends on allele coverage.
- *1: normal function
- *1: normal function
*1/*1
CYP2C19 *1/*1 maps to normal metabolizer in the prototype resolver.
Panel genotyping selected; phenotype confidence depends on allele coverage.
- *1: normal function
- *1: normal function
unknown
CYP2B6 could not be resolved confidently; the engine lowers confidence instead of assuming a phenotype.
Panel genotyping selected; phenotype confidence depends on allele coverage.
No-call or missing diplotype.
This prototype maps common star-allele diplotypes to metabolizer phenotypes locally. Functional phenotypes may differ from genetic phenotypes after phenoconversion modeling from current medications.
Current medication section
Strong CYP2D6 inhibitors such as fluoxetine, paroxetine, and bupropion can phenoconvert CYP2D6 in the scoring engine.
Clinical risk factor section
Safety rules can override numerical scores.
Dose context
Dose context is optional. Missing dose lowers confidence; high-dose or fast-titration context can strengthen caution language.
Prior treatment section
Prior response, adequate no-response, and severe adverse events affect confidence and ranking but do not override hard safety gates.
Prior adequate no-response / failed antidepressants
Prior good response
Drugs with prior adverse effects
Adverse effects
Preferences section
Preferences can reorder close options, but they cannot override hard safety rules.