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Source registry

Evidence source metadata used by rule validation and scoring weights. Generated ClinPGx sources are loaded with local source metadata.

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ClinPGx source import

The app evaluates patients locally from generated JSON files; it does not send patient data to ClinPGx.

Last sync

2026-05-15T13:30:10.585Z

API base

https://api.pharmgkb.org

License note

CC BY-SA 4.0

Sources

Evidence tiers influence how strongly score deltas are applied; hard safety rules still override ranking.

cpic_sri_2023

CPIC Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants

Clinical Pharmacogenetics Implementation Consortium · clinical_guideline · 2023 · tier guideline_high

Used for high-confidence CYP2C19/CYP2D6/CYP2B6 antidepressant PGx concepts. SLC6A4/HTR2A are documented but not used for ranking in this prototype.

Last reviewed: 2026-05-14

cpic_tca_2016

CPIC Guideline for CYP2D6, CYP2C19 and Tricyclic Antidepressants

Clinical Pharmacogenetics Implementation Consortium · clinical_guideline · 2016 update · tier guideline_high

Used for TCA CYP2D6/CYP2C19 exposure and combined-gene caution concepts.

Last reviewed: 2026-05-14

fda_citalopram_label

FDA label concept for citalopram QT and CYP2C19 poor-metabolizer exposure risk

US FDA / DailyMed label information · regulatory_label · current label concept reviewed 2026-05-14 · tier label

Used for citalopram QT and CYP2C19 poor-metabolizer safety gate concepts.

Last reviewed: 2026-05-14

dailymed_bupropion_label

DailyMed label concept for bupropion seizure contraindication

US National Library of Medicine DailyMed · regulatory_label · current label concept reviewed 2026-05-14 · tier label

Used for bupropion seizure-history hard-stop prototype rule.

Last reviewed: 2026-05-14

pharmgkb_clinpgx_annotation

PharmGKB / ClinPGx clinical annotation concept

PharmGKB / ClinPGx · clinical_annotation · reviewed 2026-05-14 · tier pharmgkb_annotation

Used for lower-confidence annotations and cross-checking source hierarchy.

Last reviewed: 2026-05-14

mechanistic_cyp_pathways

Mechanistic CYP pathway model for antidepressant clearance

PGxAI Clinical Engine v2 · mechanistic_model · 2.0.0 · tier mechanistic

Approximate pathway weights for transparent exposure modeling. These are intentionally lower-weight than guideline or label rules.

Last reviewed: 2026-05-14

local_demo_rulebase_v2

Local educational demo rulebase

PGxAI Clinical Engine v2 · local_heuristic · 2.0.0 · tier local_demo

Used for preference, missing-data, answer-quality, and limited-coverage fallback logic. It should not be interpreted as clinical guidance.

Last reviewed: 2026-05-14

clinpgx_clinical_annotation